This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015]
Catalog No
D12069
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
Modification
Acetyl Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
XPO1; CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog
Molecular Weight (Da)
123386
Gene Name
XPO1
Protein Name
Exportin-1
Human Gene ID
7514
Human Swiss Prot No.
O14980
Immunogen
Synthesized acetyl-peptide derived from the Internal region of human CRM1 around the acetylation site of K568.
Specificity
Acetyl-CRM1 (K568) Polyclonal Antibody detects endogenous levels of CRM1 protein only when acetylation at K568.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Western Blot analysis of HEPG2-UV cells using Acetyl-CRM1 (K568) Polyclonal Antibody diluted at 1:500. Secondary antibody(catalogNo.:SA0002) was diluted at 1:20000
Western Blot analysis of HepG2-UV, mouse brain cells using Acetyl-CRM1 (K568) Polyclonal Antibody. Antibody was diluted at 1:500. Secondary antibody(catalogNo.:SA0002) was diluted at 1:20000
