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Primary Antibodies
Cleaved-Caspase-1 (D210) Antibody
Cleaved-Caspase-1 (D210) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: L0114
Reactivity:Human,Mouse,Rat
Applications:WB,IF,IHC,ELISA
Modification:Cleaved Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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Tumor Suppressors/Apoptosis
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Cleaved-Caspase-1 (D210) Antibody

Immunofluorescence analysis of Human-breast-cancer tissue. 1,Cleaved-Caspase-1 (D210) Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
Cleaved-Caspase-1 (D210) Antibody
Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
Catalog No
L0114
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Cleaved Specific
Applications
WB, IF, IHC, ELISA
Dilution
WB 1:500-2000, IHC 1:50-300, IF 1:50-300
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45
Molecular Weight (Da or kDa)
Gene Name
CASP1
Protein Name
Caspase1
Human Gene ID
834
Human Swiss Prot No.
P29466
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase-1. AA range:161-210
Specificity
Cleaved-Caspase-1 (D210) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (19)
Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression WB Human 1:1000 /HCT116, HT-29 cells

Author: Available in link provided

Date of Publication : Available in link provided

Mechanism of METTL3-Mediated m6A Modification in Cardiomyocyte Pyroptosis and Myocardial Ischemia–Reperfusion Injury Cardiovasc Drug Ther. 2022 Jan;:1-14. WB Rat 1:1000 myocardial tissue

Author: Available in link provided

Date of Publication : Available in link provided

Role of Stat3 in NLRP3/caspase-1-mediated hippocampal neuronal pyroptosis in epileptic mice Synapse. 2021 Dec;75(12):e22221. WB Mouse 1:1000 hippocampus

Author: Available in link provided

Date of Publication : Available in link provided

Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway Frontiers in Endocrinology Rui-Rui Wang WB Mouse

Author: Available in link provided

Date of Publication : Available in link provided

HHcy Induces Pyroptosis and Atherosclerosis via the Lipid Raft-Mediated NOX-ROS-NLRP3 Inflammasome Pathway in apoE−/− Mice Cells Hongmei Tan IF Mouse,Human

Author: Available in link provided

Date of Publication : Available in link provided

Role of Transcription Factor Nrf2 in Pyroptosis in Spinal Cord Injury by Regulating GSDMD NEUROCHEMICAL RESEARCH Yi Liao WB Mouse,Rat

Author: Available in link provided

Date of Publication : Available in link provided

Stat5 inhibits NLRP3-mediated pyroptosis to enhance chemoresistance of breast cancer cells via promoting miR-182 transcription Chemical Biology & Drug Design Peng Wan WB Human MCF7/PTX cell,MDA-MB-231/DDP cell

Author: Available in link provided

Date of Publication : Available in link provided

LncRNA SNHG3 Promotes Sevoflurane-Induced Neuronal Injury by Activating NLRP3 via NEK7 NEUROCHEMICAL RESEARCH Hu Na WB Mouse neurons

Author: Available in link provided

Date of Publication : Available in link provided

HDAC1 participates in polycystic ovary syndrome through histone modification by regulating H19/miR-29a-3p/NLRP3-mediated granulosa cell pyroptosis. Jiying Chen WB Mouse,Human 1:500 ovarian tissue HGL5 cell

Author: Available in link provided

Date of Publication : Available in link provided

miR-20b attenuates airway inflammation by regulating TXNIP and NLRP3 inflammasome in ovalbumin-induced asthmatic mice. Yun Sun WB Mouse 1:500 Lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

GP73 enhances the ox-LDL-induced inflammatory response in THP-1 derived macrophages via affecting NLRP3 inflammasome signaling. Xiao-dong Zhuang IF Human artery

Author: Available in link provided

Date of Publication : Available in link provided

Targeting the mechanism of IRF3 in sepsis-associated acute kidney injury via the Hippo pathway. Xingui Dai WB Human HK-2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy. Autophagy Xiao Yu WB Mouse Achilles tendon Peritoneal macrophages

Author: Available in link provided

Date of Publication : Available in link provided

Downregulation of RCN1 promotes pyroptosis in acute myeloid leukemia cells. Molecular Oncology Qiaoxia Zhang WB Human OCI/AML3 cell,NB4 cell

Author: Available in link provided

Date of Publication : Available in link provided

Yueliang Yin Ameliorates Endometrial Receptivity in Mice with Embryo Implantation Failure by Reducing Pyroptosis and Activating BDNF/TrkB Pathway. MOLECULAR NUTRITION & FOOD RESEARCH Ting Wang WB Mouse uterus

Author: Available in link provided

Date of Publication : Available in link provided

Rutin prevents pyroptosis and M1 microglia via Nrf2/Mac-1/caspase-1-mediated inflammasome axis to improve POCD INTERNATIONAL IMMUNOPHARMACOLOGY Yelong Ji WB Mouse hippocampus BV2 cell

Author: Available in link provided

Date of Publication : Available in link provided

KLF5-mediated pyroptosis of airway epithelial cells leads to airway inflammation in asthmatic mice through the miR-182–5p/TLR4 axis MOLECULAR IMMUNOLOGY Zhi Lin WB Mouse 1:500 Lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

An Amino Acids and Dipeptide Injection Inhibits the TNF-α/HMGB1 Inflammatory Signaling Pathway to Reduce Pyroptosis and M1 Microglial Polarization in POCD Mice: the Gut to the Brain MOLECULAR NEUROBIOLOGY Ji Yelong WB Mouse BV2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome ANNALS OF MEDICINE Fuling Zeng WB Human 1:500 HTR-8/SVneo cell

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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