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Primary Antibodies
Cleaved-Caspase-1 p20 (N120) Antibody
Cleaved-Caspase-1 p20 (N120) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: L0143
Reactivity:Human,Rat,Mouse
Applications:WB,ELISA
Modification:Cleaved Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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Tumor Suppressors/Apoptosis
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Cleaved-Caspase-1 p20 (N120) Antibody

Western blot analysis of lysates from rat eye cells, using Caspase 1 (p20,Cleaved-Asn120) Antibody. The lane on the right is blocked with the synthesized peptide.

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Product Details
Product Name
Cleaved-Caspase-1 p20 (N120) Antibody
Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
Catalog No
L0143
Reactivity
Human, Rat, Mouse
Source
Polyclonal, Rabbit,IgG
Modification
Cleaved Specific
Applications
WB, ELISA
Dilution
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
CASP1; IL1BC; IL1BCE; Caspase-1; CASP-1; Interleukin-1 beta convertase; IL-1BC; Interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45
Molecular Weight (Da or kDa)
Gene Name
CASP1
Protein Name
Caspase1
Human Gene ID
834
Human Swiss Prot No.
P29466
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 1. AA range:101-150
Specificity
Cleaved-Caspase-1 p20 (N120) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-1 p20 protein resulting from cleavage adjacent to N120.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (4)
Achyranthoside D attenuates chondrocyte loss and inflammation in osteoarthritis via targeted regulation of Wnt3a PHYTOMEDICINE Nianhu Li WB Rat chondrocytes

Author: Available in link provided

Date of Publication : Available in link provided

Combined VEGF and bFGF loaded nanofiber membrane protects against neuronal injury and hypomyelination in a rat model of chronic cerebral hypoperfusion. INTERNATIONAL IMMUNOPHARMACOLOGY Jian Hai WB Rat 1:500 cerebral cortex

Author: Available in link provided

Date of Publication : Available in link provided

Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells Cell Death Discovery Liu Wuming WB Mouse,Rat 1:1000 pancreatic tissue AR42J cell

Author: Available in link provided

Date of Publication : Available in link provided

Effects of acetate-producing Blautia wexlerae on oxidative stress and NLRP3 inflammasome in obesity-associated male infertility MEDICAL MICROBIOLOGY AND IMMUNOLOGY Zhong Yucheng WB Mouse testicular tissue GC-1 spg cell

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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