This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]
Catalog No
L0299
Reactivity
Human, Mouse
Applications
WB, ELISA
Modification
Cleaved Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
ITIH1; IGHEP1; Inter-alpha-trypsin inhibitor heavy chain H1; ITI heavy chain H1; ITI-HC1; Inter-alpha-inhibitor heavy chain 1; Inter-alpha-trypsin inhibitor complex component III; Serum-derived hyaluronan-associated protein; SHAP
Molecular Weight (Da)
101389
Gene Name
ITIH1
Protein Name
Inter-alpha-trypsin inhibitor heavy chain H1
Human Gene ID
3697
Human Swiss Prot No.
P19827
Immunogen
The antiserum was produced against synthesized peptide derived from human ITIH1. AA range:623-672
Specificity
Cleaved-ITI-H1 (D672) Polyclonal Antibody detects endogenous levels of fragment of activated ITI-H1 protein resulting from cleavage adjacent to D672.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Western blot analysis of lysates from Jurkat cells, treated with etoposide 25uM 24h, using ITIH1 (Cleaved-Asp672) Antibody. The lane on the right is blocked with the synthesized peptide.
