This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. HypoMethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
Catalog No
L0377
Reactivity
Human, Rat, Mouse
Applications
WB, ELISA
Modification
Cleaved Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Western blot analysis of lysates from NIH/3T3 cells, treated with etoposide 25uM 1h, using PAR4 (Cleaved-Gly48) Antibody. The lane on the right is blocked with the synthesized peptide.
