This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Catalog No
A0772
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
ATRIP; AGS1; ATR-interacting protein; ATM and Rad3-related-interacting protein
Molecular Weight (Da)
85838
Gene Name
ATRIP
Protein Name
ATR-interacting protein
Human Gene ID
84126
Human Swiss Prot No.
Q8WXE1
Immunogen
The antiserum was produced against synthesized peptide derived from human ATRIP around the phosphorylation site of Ser68. AA range:34-83
Specificity
Phospho-ATRIP (S68) Polyclonal Antibody detects endogenous levels of ATRIP protein only when phosphorylated at S68.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using ATRIP (Phospho-Ser68) Antibody
