This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Catalog No
A8042
Reactivity
Human, Mouse, Rat
Applications
IHC-p, IF(paraffin section), ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221
Molecular Weight (Da)
154793
Gene Name
IGF1R
Protein Name
Insulin-like growth factor 1 receptor
Human Gene ID
3480
Human Swiss Prot No.
P08069
Immunogen
The antiserum was produced against synthesized peptide derived from human IGF1R around the phosphorylation site of Tyr1346. AA range:1311-1360
Specificity
Phospho-IGF-IR (Y1346) Polyclonal Antibody detects endogenous levels of IGF-IR protein only when phosphorylated at Y1346.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Immunohistochemistry analysis of paraffin-embedded human brain, using IGF1R (Phospho-Tyr1346) Antibody. The picture on the right is blocked with the phospho peptide.
Enzyme-Linked Immunosorbent Assay (Phospho-ELISA) for Immunogen Phosphopeptide (Phospho-left) and Non-Phosphopeptide (Phospho-right), using IGF1R (Phospho-Tyr1346) Antibody